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Catalog No. T14303Cas No. 1818393-16-6
Alrizomadlin (APG-115) is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner.
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Pack SizePriceAvailabilityQuantity
1 mg$263In Stock
5 mg$619In Stock
10 mg$888In Stock
25 mg$1,270In Stock
50 mg$1,530In Stock
100 mg$1,990In Stock
1 mL x 10 mM (in DMSO)$786In Stock
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Product Introduction

Alrizomadlin (APG-115) is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner.
In vitro
Alrizomadlin (0.001-100 μM) inhibits cell proliferation in a concentration-dependent manner(IC50s: 18.9 nM and 103.5 ± 18.3 nM respectively in AGS and MKN45 cells). Alrizomadlin (0.02-0.2 μM) activates p53 to enhance radiosensitivity in AGS and MKN45 cells and enhances the anti-proliferative effect of radiotherapy at different radiation doses. Stable knockout of p53 abrogates expression of MDM2, p53, p21, PUMA, BAX, Cleaved-caspase3, γH2AX. Alrizomadlin affects progression by inducing cells arrested at G0/G1 phase[3]. Alrizomadlin (0.3 μM-10 μM) leads to a concentration-dependent cell cycle arrest in G2/M phases and decreases S-phase in p53 wide-type cell lines (TPC-1, KTC-1)[4].
In vivo
In male BALB/c athymic nude mice with MKN45 cells, Alrizomadlin (100 mg/kg; orally) enhances radiation antitumor effect in gastric adenocarcinoma[3].
AliasAPG-115, AA-115
Chemical Properties
Molecular Weight642.59
Cas No.1818393-16-6
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 90 mg/mL (140.1 mM)
Solution Preparation Table
1 mM1.5562 mL7.7810 mL15.5620 mL77.8101 mL
5 mM0.3112 mL1.5562 mL3.1124 mL15.5620 mL
10 mM0.1556 mL0.7781 mL1.5562 mL7.7810 mL
20 mM0.0778 mL0.3891 mL0.7781 mL3.8905 mL
50 mM0.0311 mL0.1556 mL0.3112 mL1.5562 mL
100 mM0.0156 mL0.0778 mL0.1556 mL0.7781 mL


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