Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 95.00 | |
50 mg | In stock | $ 166.00 | |
100 mg | In stock | $ 249.00 | |
200 mg | In stock | $ 373.00 | |
500 mg | In stock | $ 628.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 55.00 |
Description | Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo. |
In vitro | Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) [1]. |
In vivo | Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2]. |
Synonyms | Periodate-oxidized adenosine, Adenosine, periodate oxidized, Adenox, Adenosinedialdehyde |
Molecular Weight | 265.23 |
Formula | C10H11N5O4 |
CAS No. | 34240-05-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (33.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Adenosine Dialdehyde (ADOX) 34240-05-6 Others ADOX Adenosine Dialdehyde Periodate-oxidized adenosine Adenosine, periodate oxidized Adenox Adenosinedialdehyde inhibitor inhibit