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ATC 0175 hydrochloride

Catalog No. T22591   CAS 510733-97-8

ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, <10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders.

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ATC 0175 hydrochloride Chemical Structure
ATC 0175 hydrochloride, CAS 510733-97-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 72.00
5 mg In stock $ 163.00
10 mg In stock $ 263.00
25 mg In stock $ 538.00
50 mg In stock $ 913.00
100 mg In stock $ 1,490.00
500 mg In stock $ 2,990.00
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Purity: 99.84%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, >10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders.
Targets&IC50 MCH1:13 nM, 5-HT2B:9.66 nM, 5-HT1A:16.9 nM
In vitro In vitro, assays showed that this compound is a potent antagonist with a high affinity for MCH1R. The receptor binding and the functional assay (MCH-induced increase in [Ca2+]) indicated that ATC0175 is a noncompetitive antagonist at MCH1Rs.[1]
In vivo ATC0175 (1, 3, 10 mg/kg ; p.o. ) treatment also exhibited antidepressant effects in the forced swimming test.[2]
ATC0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia.[2]
Molecular Weight 461.93
Formula C23H26ClF2N5O
CAS No. 510733-97-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 22.5 mg/mL (48.7 mM)

DMSO: 9.0 mg/mL (19.4 mM)

TargetMolReferences and Literature

1. Semple G, et al. Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation. Bioorg Med Chem Lett. 2009 ; 19(21):6166-6171. 2. Chaki S, et al. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 ; 11(4):341-352.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library Anti-Obesity Compound Library Neurotransmitter Receptor Compound Library

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Keywords

ATC 0175 hydrochloride 510733-97-8 Endocrinology/Hormones GPCR/G Protein Neuroscience GPR 5-HT Receptor Melanin-concentrating Hormone Receptor (MCHR) ATC-0175 Hydrochloride ATC 0175 Hydrochloride ATC0175 Hydrochloride inhibitor inhibit

 

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