Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, <10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 72.00 | |
5 mg | In stock | $ 163.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 538.00 | |
50 mg | In stock | $ 913.00 | |
100 mg | In stock | $ 1,490.00 | |
500 mg | In stock | $ 2,990.00 |
Description | ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, >10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders. |
Targets&IC50 | MCH1:13 nM, 5-HT2B:9.66 nM, 5-HT1A:16.9 nM |
In vitro | In vitro, assays showed that this compound is a potent antagonist with a high affinity for MCH1R. The receptor binding and the functional assay (MCH-induced increase in [Ca2+]) indicated that ATC0175 is a noncompetitive antagonist at MCH1Rs.[1] |
In vivo |
ATC0175 (1, 3, 10 mg/kg ; p.o. ) treatment also exhibited antidepressant effects in the forced swimming test.[2] ATC0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia.[2] |
Molecular Weight | 461.93 |
Formula | C23H26ClF2N5O |
CAS No. | 510733-97-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 22.5 mg/mL (48.7 mM)
DMSO: 9.0 mg/mL (19.4 mM)
You can also refer to dose conversion for different animals. More
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ATC 0175 hydrochloride 510733-97-8 Endocrinology/Hormones GPCR/G Protein Neuroscience GPR 5-HT Receptor Melanin-concentrating Hormone Receptor (MCHR) ATC-0175 Hydrochloride ATC 0175 Hydrochloride ATC0175 Hydrochloride inhibitor inhibit