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8-Bromo-cGMP sodium

Catalog No. T14064   CAS 51116-01-9

8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.

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8-Bromo-cGMP sodium Chemical Structure
8-Bromo-cGMP sodium, CAS 51116-01-9
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10 mg In stock $ 89.00
25 mg In stock $ 178.00
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Purity: 99.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.
In vitro 8-Bromo-cGMP sodium (1 µM-0.1 mM) can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[1]
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.[2]
8-Bromo-cGMP sodium (1-100 μM; 8 h) increases the resistance of LLC-PK1 cells to CsA toxicity in concentration-dependently.[2]
In vivo 8-Bromo-cGMP sodium (0.3, 1, 3 nM; intrathecal administration; 10 min before the test; male ICR mice) significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice in dose-dependently.[3]
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in WT littermates and eNOS-Tg mice in C57BL/6 background (19-35 g).[4]
Molecular Weight 447.09
Formula C10H11BrN5NaO7P
CAS No. 51116-01-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: H2O : 90.0 mg/mL (201.8 mM), sonification is recommended.

TargetMolReferences and Literature

1. Choi J, et al. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. J Pharmacol Exp Ther. 1998;285(2):588-594. 2. Polte T, et al. Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1. Free Radic Biol Med. 2002;32(1):56-63. 3. Kamei J, et al. Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice. Pain. 2005;117(1-2):112-120. 4. van Deel ED, et al. Vasomotor control in mice overexpressing human endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2007;293(2):H1144-H1153. 5. Sarkar O, et al. Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017;12(7):e0179301. 6. Tegeder I, et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002;332(2):146-150.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

8-Bromo-cGMP sodium 51116-01-9 Membrane transporter/Ion channel Metabolism Tyrosine Kinase/Adaptors Calcium Channel PKA 8 Bromo cGMP sodium 8BromocGMP sodium inhibitor inhibit

 

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