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5-ALA benzyl ester hydrochloride

Catalog No. T19147 CAS 163271-32-7

Synonyms: Benzyl-ALA hydrochloride

5-ALA benzyl ester hydrochloride is a protoporphyrin precursor. 5-ALA benzyl ester hydrochloride is used as a photodetection agent. 5-ALA benzyl ester hydrochloride could induce protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines.

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5-ALA benzyl ester hydrochloride, CAS 163271-32-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 31.00
10 mg	In stock	$ 51.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 178.00
100 mg	In stock	$ 297.00
200 mg	In stock	$ 455.00
500 mg	In stock	$ 736.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 98.72%

Purity: 97.11%

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Storage & Solubility Information

Description	5-ALA benzyl ester hydrochloride is a protoporphyrin precursor. 5-ALA benzyl ester hydrochloride is used as a photodetection agent. 5-ALA benzyl ester hydrochloride could induce protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines.
In vitro	In colon carcinoma cell lines SW480, 5-ALA benzyl ester hydrochloride (0.6-0.12 mM; 3h) induces PPIX accumulation[1].
In vivo	In female CBA/Gy mice, 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v.; 1h) results in a dose-dependent reduction in tumour porphyrin levels[2].
Animal Research	Animal Model: Female CBA/Gy mouse (CaNT tumour model) Dosage: 31 mg/kg Administration: i.v. ; 1 hours [3]

Synonyms	Benzyl-ALA hydrochloride
Molecular Weight	257.71
Formula	C12H16ClNO3
CAS No.	163271-32-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 245 mg/mL (950.68 mM), Need ultrasonic

H2O: 95 mg/mL (368.63 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Brunner H, et al. The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines. Photochem Photobiol. 2001 Nov;74(5):721-5. 2. Tunstall RG, et al. Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo. Br J Cancer. 2002 Jul 15;87(2):246-50. 3. Hirschberg H, et al. ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids. J Neurooncol. 2002 Mar;57(1):1-7.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

5-ALA benzyl ester hydrochloride 163271-32-7 Metabolism Others Endogenous Metabolite accumulation 5 ALA benzyl ester hydrochloride SW480 photodetection protoporphyrin Benzyl-ALA hydrochloride 5-ALA benzyl ester Inhibitor inhibit Benzyl-ALA colon 5ALA benzyl ester hydrochloride carcinoma inhibitor

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