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Immunology / Inflammation COX 4',7-Dihydroxyflavone

4',7-Dihydroxyflavone

Catalog No. TN1273   CAS 2196-14-7
Purity 99.60% Datasheet

4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.

4',7-Dihydroxyflavone, CAS 2196-14-7
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5 mg In stock 121.00
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Purity 98.00%
Purity 99.60%
Biological Description
Chemical Properties
Storage & Solubility Information
Description 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
Targets&IC50 COX,   NOD1,  
In vitro Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti. Indentities of major nod inducers were established by spectroscopic analyses (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy) and comparison with authentic standards. Major nod inducers, which were identified as 4',7-Dihydroxyflavone, 4'-7-dihydroxyflavanone, and 4,4'-dihydroxy-2'-methoxychalcone, were released from seedling roots at 54, 22, and 20 picomole.plant(-1).day(-1), respectively. Luteolin was not found in these root exudates.
Synonyms
Purity 99.60%
Appearance solid
Molecular Weight 254.10
Formula C15H10O4
CAS No. 2196-14-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 250 mg/mL (983.32 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. A Chalcone and Two Related Flavonoids Released from Alfalfa Roots Induce nod Genes of Rhizobium meliloti.Plant Physiol., 1989, 91(3):842-7.

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