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2'-Deoxycytidine hydrochloride

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Catalog No. T22494Cas No. 3992-42-5
Alias Deoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochloride

2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).

2'-Deoxycytidine hydrochloride
Other Forms of 2'-Deoxycytidine hydrochloride:

2'-Deoxycytidine hydrochloride

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Purity: 98.96%
Catalog No. T22494Alias Deoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochlorideCas No. 3992-42-5
2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$29-In Stock
1 mL x 10 mM (in DMSO)$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.96%
Appearance:Solid
Color:White
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).
In vitro
Methods: Effects of 2'-Deoxycytidine hydrochloride (1 mM) on the cytotoxicity of 5FU against mouse myeloma SP2/0-Ag14 (SP2/0) cells lacking hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) and RH4 hybridoma cells possessing HGPRT under asynchronous conditions.
Results: In both SP2/0 and RH4 cells, 5FU-reduced cell viability was restored by co-treatment but not pre-treatment with 2'-Deoxycytidine hydrochloride, but the effect of the former was often greater than that of the latter, suggesting that HGPRT may be involved in the interaction, although this may not be the primary mechanism. [1]
SynonymsDeoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochloride
Chemical Properties
Molecular Weight263.68
FormulaC9H14ClN3O4
Cas No.3992-42-5
SmilesO=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=CC(N)=N1.Cl
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 30 mg/mL (113.77 mM), Sonication is recommended.
DMSO: 20 mg/mL (75.85 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.58 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.7925 mL18.9624 mL37.9248 mL189.6238 mL
5 mM0.7585 mL3.7925 mL7.5850 mL37.9248 mL
10 mM0.3792 mL1.8962 mL3.7925 mL18.9624 mL
20 mM0.1896 mL0.9481 mL1.8962 mL9.4812 mL
50 mM0.0758 mL0.3792 mL0.7585 mL3.7925 mL
H2O
1mg5mg10mg50mg
100 mM0.0379 mL0.1896 mL0.3792 mL1.8962 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

2'-Deoxycytidine Hydrochloride2'Deoxycytidine hydrochloride2' Deoxycytidine hydrochloride
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