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(+)-Magnoflorine
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Catalog No. T3S1319Cas No. 2141-09-5
Alias Thalictrin, Magnoflorine, Escholine, Escholin
(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance.
(+)-Magnoflorine
Copy Product Info🥰Excellent
Purity: 99.99%
Catalog No. T3S1319Alias Thalictrin, Magnoflorine, Escholine, EscholinCas No. 2141-09-5
(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $33 | In Stock | In Stock | |
| 5 mg | $50 | In Stock | In Stock | |
| 10 mg | $70 | In Stock | In Stock | |
| 25 mg | $115 | In Stock | In Stock | |
| 50 mg | $182 | In Stock | In Stock | |
| 100 mg | $290 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $60 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.99%
Appearance:Solid
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Product Introduction
(+)-Magnoflorine AI Summary
(+)-Magnoflorine exhibits a range of biological activities and potential therapeutic properties. It shows cytotoxicity against human Hep G2.2.15 cells, with a CC50 value greater than 4,114,000.0 nM, and antiviral activity against HBV transfected cells inhibiting surface antigen HBsAg and e antigen HBsAg secretion, with IC50 values also greater than 4,114,000.0 nM. In ip dosed mice, it has a toxicity profile with an LD50 value of 19.6 mg/kg, causing labored breathing and depression within 5 minutes and leading to death after 15 minutes at this dosage. The compound also exhibits antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains with an ED50 value greater than 10,000.0 ng/mL. Additionally, 399568 affects the growth and morphogenesis of organogenesis-staged rat embryos at concentrations from 1.25 μg/mL to 80 μg/mL, showing mild developmental impact after 45 hours of exposure. It demonstrates antiamoebic activity against Entamoeba histolytica with an IC50 value of 37.96 μg/mL. Furthermore, it induces significant p38 MAPK phosphorylation in mouse C2C12 cells at a concentration of 0.1 nM after 2 days, with a fold change of 6.0. (+)-Magnoflorine shows pronounced anti-inflammatory and anti-apoptotic activities, inhibiting TNF-alpha/IFN-gamma-induced apoptosis in human HaCaT cells and providing protection against DNCB-induced skin inflammation in a mouse model of atopic dermatitis. This diverse activity profile suggests its potential therapeutic applications in conditions involving inflammation, apoptosis, and other pathogenic processes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance. |
| Synonyms | Thalictrin, Magnoflorine, Escholine, Escholin |
| Molecular Weight | 342.41 |
| Formula | C20H24NO4 |
| Cas No. | 2141-09-5 |
| Smiles | OC1=C2C=3[C@](CC=4C2=C(O)C(OC)=CC4)([N+](C)(C)CCC3C=C1OC)[H] |
| Relative Density. | no data available |
| Storage | keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 34.24 mg/mL (100 mM), Sonication is recommended.  Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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