Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T1621	Imatinib Mesylate	220127-57-1	99.73%
T1621	Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, re...
T1664	Meglutol	503-49-1	99.73%
T1664	Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by...
T7083	GLPG1837	1654725-02-6	99.73%
T7083	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T0302	Triflupromazine hydrochloride	1098-60-8	99.73%
T0302	Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T4546	Dinoprost tromethamine salt	38562-01-5	99.73%
T4546	Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
TQ0181	Resatorvid	243984-11-4	99.73%
TQ0181	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereb...
T1872	Fenretinide	65646-68-6	99.72%
T1872	Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T1284	Megestrol acetate	595-33-5	99.72%
T1284	Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic pr...
T2595	Lumacaftor	936727-05-8	99.72%
T2595	Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (...
T0618	Indole-3-Glyoxylyl Chloride	22980-09-2	99.72%
T0618	Indole-3-glyoxylyl chloride (3-Indoleglyoxylyl chloride) can be used in chemical synthesis, such as bisindolylmaleimide.
T3043	Ruxolitinib phosphate	1092939-17-7	99.72%
T3043	Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fo...
T1058	Carboplatin	41575-94-4	99.72%
T1058	Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death...
T23358	Sitagliptin phosphate	654671-78-0	99.72%
T23358	Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.
T2732	(-)-Epicatechin gallate	1257-08-5	99.72%
T2732	(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins...
T0942	Quinacrine dihydrochloride	69-05-6	99.72%
T0942	Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and...
T0429	Glucosamine	3416-24-8	99.72%
T0429	Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine ...
T0607	Dihydroartemisinin	71939-50-9	99.72%
T0607	Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.
T9207L	GW406108X(Z/E)	265098-01-9	99.71%
T9207L	GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
T2534	Pitavastatin calcium	147526-32-7	99.71%
T2534	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol i...
T2888	Pterostilbene	537-42-8	99.71%
T2888	Pterostilbene is extracted from Pterocarpus indicus.