nsp1 — TargetMol Chemicals

Cat No.	Product Name	Targets
T79526	SARS-CoV-2 nsp14-IN-4	SARS-CoV
	SARS-CoV-2 nsp14-IN-4 (Compound 12q), a non-cytotoxic and cell-permeable inhibitor of SARS-CoV-2 nsp14 methyltransferase (IC50 = 19 nM), is employed in COVID-19 research [1].	SARS-CoV
T62413	SARS-CoV-2 nsp13-IN-1
	SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13). SARS-CoV-2 nsp13-IN-1 inhibits only nsp13 ssDNA+ATPase (IC50: 6 μM), but not ssDNA-ATPase. CoV-2 nsp13-IN-1 was able to be u...
T62829	SARS-CoV-2 nsp14-IN-1
	SARS-CoV-2 nsp14-IN-1 (Compound 3) is a typical dual-substrate inhibitor of SARS-CoV-2Nsp14 Mtase (IC50: 0.061 μM). Histone lysine, protein arginine, DNA and RNA, etc.).
T62375	SARS-CoV-2 nsp13-IN-3
	SARS-CoV-2 nsp13-IN-3 (Compound C3) is a small molecule inhibitor of SARS-CoV-2 non-structural protein 13 (nsp13) that acts on nsp13 ssDNA+ATPase (IC50: 32 μM).
T62031	SARS-CoV-2 nsp13-IN-4
	SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective small-molecule inhibitor of nsp13 helicase. SARS-CoV-2 nsp13-IN-4 inhibits the ssDNA+ ATPase activity of nsp13 with an IC 50 of 57 μM. SARS-CoV-2 nsp13-IN-4 can pr...
T62248	SARS-CoV-2 nsp13-IN-6
	SARS-CoV-2 nsp13-IN-6 (compound C5) is a potent inhibitor of SARS-CoV-2 non-structural protein 13 (nsp13) that acts on ssDNA+ATPase (IC50: 27 μM) and ssDNA-ATPase (IC50: 33 μM). nsp13-IN-6 can be used in anti-COVID-19 st...
T62819	SARS-CoV-2 nsp14-IN-2
	SARS-CoV-2 nsp14-IN-2 is a potent inhibitor of SARS-CoV-2 Nsp14 methyltransferase (IC50: 0.093 μM). SARS-CoV-2 nsp14-IN-2 has the potential to be used in COVID-19 studies.
T78725	SARS-CoV-2 nsp14-IN-3	SARS-CoV
	SARS-CoV-2 nsp14-IN-3 (4975) is a potent inhibitor targeting the N7-Methyltransferase activity of SARS-CoV-2 nonstructural protein 14 (Nsp14), with an IC50 value of 3.5 μM [1].	SARS-CoV
T62264	SARS-CoV-2 nsp13-IN-2
	SARS-CoV-2 nsp13-IN-2 (Compound C2) is a small molecule inhibitor of SARS-CoV-2 non-structural protein 13 (nsp13) that acts on nsp13 ssDNA+ATPase (IC50: 42 μM).
T63615	SARS-CoV-2 nsp13-IN-5
	SARS-CoV-2 nsp13-IN-5 is a potent inhibitor of SARS-CoV-2 nsp13, capable of acting on ssDNA+ATPase (IC50: 50 μM) and ssDNA-ATPase (IC50: 55 μM). SARS-CoV-2 nsp13-IN-5 can be used in anti-COVID-19 studies.

Compounds

SARS-CoV-2 nsp14-IN-4

T79526

Synonym:

Target: SARS-CoV

SARS-CoV-2 nsp13-IN-1

T62413

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Target:

SARS-CoV-2 nsp14-IN-1

T62829

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SARS-CoV-2 nsp13-IN-3

T62375

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SARS-CoV-2 nsp13-IN-4

T62031

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SARS-CoV-2 nsp13-IN-6

T62248

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SARS-CoV-2 nsp14-IN-2

T62819

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SARS-CoV-2 nsp14-IN-3

T78725

Synonym:

Target: SARS-CoV

SARS-CoV-2 nsp13-IN-2

T62264

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SARS-CoV-2 nsp13-IN-5

T63615

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Target:

Recombinant Proteins

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Expression System：

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Cat No.	Product Name	Species	Expression System
TMPJ-01425	SARS-CoV-2 NSP1 Protein (His)	SARS-CoV-2	E. coli
	The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, po...
TMPK-01384	SARS PLpro/papain-like protease Protein (His)	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPK-01352	SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPY-06012	SARS-CoV-2 NSP10 Protein	SARS-CoV-2	E. coli
	NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp...
TMPY-06011	SARS-CoV-2 NSP10 Protein (His)	SARS-CoV-2	E. coli
	NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp...
TMPY-06009	SARS-CoV-2 NSP7 Protein	SARS-CoV-2	E. coli
	NSP7 is conserved within the coronaviridae. NSP7 is a component of the coronavirus replicase polyprotein to comprise a repilication complex. NSP7 has been shown to interact with NSP10 and NSP1 which indicate that NSP7 ha...