neurokinin-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23316	SB 218795		Neurokinin receptor
	SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.		Neurokinin receptor
TP1086	Men 10376 TFA(135306-85-3,free)	Men 10376 TFA,Neurokinin-2 receptor antagonist TFA	Neurokinin receptor
	Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.		Neurokinin receptor
T38144	Elinzanetant		Neurokinin receptor
	Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.		Neurokinin receptor
T15278	Fezolinetant	ESN-364	Neurokinin receptor
	Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.		Neurokinin receptor
TP1851L	Scyliorhinin II acetate		Neurokinin receptor
	Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.		Neurokinin receptor
T16114	Pavinetant	AZD4901,MLE-4901,AZD2624	MEK
	Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrome (PCOS), which is a potential compound for the treatment o...		MEK
T8235	L-732138		Neurokinin receptor
	L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)		Neurokinin receptor
T76635	(Trp7,β-Ala8)-Neurokinin A (4-10)
	(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent neurokinin-3 (NK3) antagonist [1] .
T70231	Osanetant HCl
	Osanetant HCl is the (R)-enantiomer; neurokinin-3 receptor antagonist
T28676	SB 235375	SB-235375,SB235375
	SB 235375 is a potent and selective antagonist of neurokinin-3 receptor with a low central nervous system-penetrant.
T76436	[MePhe7]-Neurokinin B
	[MePhe7]-Neurokinin B is a neurokinin NK-3 receptor (NK3R) agonist, exhibiting a potent agonistic activity with an IC50 value of 3 nM. It acts as a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) s...
T76426	[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
	[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, serves as a selective and potent agonist for the NK2 receptor (NK2R). This compound exhibits prokinetic activity, making it a valuable tool for re...
T76405	[D-Trp2,7,9] Substance P
	[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist that exhibits inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1].
T76431	GR 83074
	GR 83074 is a potent and selective antagonist of the NK-2 (Neurokinin Receptor), demonstrating a selectivity factor of 340-fold over NK-1, with a pK B value of 8.23. It does not act as an antagonist for NK-3, affirming i...
T36053	D-Lysine lactam
	D-Lysine lactam is a chiral building block.1,2It has been used in the synthesis of a chiral antibiotic synthetic intermediate, as well as in the stereoselective synthesis of neurokinin (NK) receptor antagonists. 1.Kumar,...
T32007	GSK256471	GSK 256471,GSK-256471
	GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment sho...
T76404	[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
	[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. T...