Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 347.00 | |
50 mg | In stock | $ 563.00 | |
100 mg | In stock | $ 793.00 | |
500 mg | In stock | $ 1,670.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 146.00 |
Description | SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1. |
Targets&IC50 | NK3 (human):13 nM (Ki), NK2 (human):1220 nM (Ki) |
In vitro | SB 218795 (3-30 nM) antagonizes the contractile responses senktide-induced in a surmountable and concentration-dependent manner[1]. |
In vivo | In rabbits, SB 218795 (0.25-1 mg/kg; i.v.) inhibits NK3 receptor-mediated pupillary constriction by maximum inhibition of 78%[1]. |
Molecular Weight | 396.44 |
Formula | C25H20N2O3 |
CAS No. | 174635-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 5 mM
DMSO: 100 mM
You can also refer to dose conversion for different animals. More
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SB 218795 174635-53-1 GPCR/G Protein Neuroscience Neurokinin receptor constriction Neurokinin Receptor Inhibitor neurokinin-3 NK receptor pupillary SB218795 inhibit Tachykinin receptor SB-218795 NK-3 inhibitor