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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8931L | ICCB-19 hydrochloride | ICCB-19 HCl(750621-52-4 free base) | Apoptosis , Others , Autophagy , RIP kinase |
ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal dom... | |||
T71573 | STK630921 | ||
STK630921 is a blocker of IL-17A binding to the IL-17A receptor (IL-17RA). | |||
T1757 | ML-323 | ML323 | DUB |
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (I... | |||
T82413 | FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 | AUTACs | |
FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 serves as a linker for AUTAC4, a compound comprising a p-fluorobenzylguanine (FBnG) unit and a phenylindole moiety. This construction is capable of inducing K63-linked polyub... | |||
T82632 | Cys-C-cGMP | AUTACs | |
Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1]. | |||
T74018 | CGMP-HTL | ||
cGMP-HTL, an autophagy-targeting chimera (AUTAC), consists of a HT-ligand, a linker, and a Cys-S-cGMP (autophagy tag), designed to enhance K63-linked ubiquitination of mitochondria. This novel clearance strategy features... |