hdhodh — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11031	hDHODH-IN-7	DHODH-IN-9	Dehydrogenase
	hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects.		Dehydrogenase
T11546	hDHODH-IN-1		Dehydrogenase
	hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with an anti-inflammatory effect.		Dehydrogenase
T11029	hDHODH-IN-5	DHODH-IN-7	Dehydrogenase
	hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).		Dehydrogenase
T11025	hDHODH-IN-3	DHODH-IN-2	Dehydrogenase
	hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.		Dehydrogenase
T11028	hDHODH-IN-4	DHODH-IN-5	Dehydrogenase
	hDHODH-IN-4 (DHODH-IN-5) is a potent inhibitor of human dihydrogen dehydrogenase (DHODH). For human recombinant DHODH, its pIC50 is 7.8. hDHODH-IN-4 inhibits measles virus replication with a pMIC50 of 8.8.		Dehydrogenase
T11547	hDHODH-IN-2		Others
	hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity.		Others
T64360	hDHODH-IN-8		Dehydrogenase
	hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential fo...		Dehydrogenase
T82223	hDHODH-IN-13
	hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in studying inflammatory bowel disease (IBD) [1].
T63037	hDHODH-IN-10
	hDHODH-IN-10 is a selective, orally active, potent hDHODH inhibitor (IC50: 10.9 nM) that forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells and can be used to...
T78932	hDHODH-IN-12		DNA/RNA Synthesis
	hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM. As the rate-limiting enzyme in the de novo synthesis of pyrimidines, critical for DNA...		DNA/RNA Synthesis
T61226	hDHODH-IN-9
	hDHODH-IN-9 (Compound 3k) is a highly potent inhibitor of hDHODH, exhibiting an IC50 of 0.34 μM. It displays significant cytotoxic activity against MCF-7 and A375 cells, while maintaining good selectivity. With its chara...
T72948	hDHODH-IN-11
	hDHODH-IN-11, a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 value of 7.2 nM and has low cytotoxicity. It is applicable in acute myeloid leukemia (AML) research.
T40182	Ascochlorin A	Acremochlorin A
	Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitor aimed at treating triple-negative breast cancer.