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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6828 | ZL0420 | Epigenetic Reader Domain | |
ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has IC 50 values of 27 nM against BRD4 BD1 and 32 nM against B... | |||
T36573 | NHWD-870 | Apoptosis , Epigenetic Reader Domain | |
NHWD-870 is an effective and selective inhibitor of BET family bromodomain only binding to BRD2, BRD3, BRD4 (IC50 = 2.7 nM), and BRDT. NHWD-870 exhibits potent anti-tumor efficacies and suppresses cancer cell-macrophage ... | |||
T1972 | GSK-5959 | Epigenetic Reader Domain | |
GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family... | |||
T60079 | GNE-064 | GNE064 | Epigenetic Reader Domain |
GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 pos... | |||
T3969 | I-CBP112 | Epigenetic Reader Domain , Histone Acetyltransferase | |
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains. | |||
T2436 | GSK2801 | Apoptosis , Epigenetic Reader Domain | |
GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains. | |||
T3973 | PF-CBP1 | Epigenetic Reader Domain | |
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM). | |||
T8658 | NEO2734 | EP31670 | Epigenetic Reader Domain , Histone Acetyltransferase |
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains). | |||
T1854 | MS436 | Epigenetic Reader Domain | |
MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains. | |||
T6255 | Bromosporine | Epigenetic Reader Domain , CDK | |
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively. | |||
T15784 | LP99 | Epigenetic Reader Domain | |
LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9). | |||
T4247 | I-CBP112 hydrochloride | Epigenetic Reader Domain | |
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly re... | |||
T6939 | PFI-3 | PFI 3 | Epigenetic Reader Domain |
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer. | |||
T28628 | RVX-297 | RVX297 | Epigenetic Reader Domain |
RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. | |||
T3217 | PF-CBP1 hydrochloride | PF-CBP1 HCl | Epigenetic Reader Domain , Histone Acetyltransferase |
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. | |||
T9020 | GSK620 | Epigenetic Reader Domain | |
GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD... | |||
T26758 | BDOIA383 | ||
BDOIA383 is a novel inhibitor of CBP/p300 Bromodomains. | |||
T69952 | BiBET | ||
BiBET is a potent, selective, bivalent inhibitor of BET bromodomains. | |||
T27071 | CPI571 | ||
CPI571 is a potent and selective inhibitor for the bromodomains of CREBBP/EP300. | |||
T27068 | CPI098 | CPI-098,CPI 098 | |
CPI098 is a potent and selective inhibitors for the bromodomains of CREBBP/EP300. CREBBP/EP300 bromodomains play a critical role in regulatory T cell biology. T cell recruitment to tumors is a major mechanism of immune e... |