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Search Result

Search Results for " ttr "

19

Compounds

2

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T32500 L6Y TTR stabilizer L6
L6Y is a transthyretin (TTR) stabilizer which binds to the T4 binding pocket of TTR and prevents the dissociation of TTR to monomer.
T75173 WT-TTR inhibitor 1
Compound 21, a WT-TTR (wild-type Transthyretin) inhibitor, exhibits a 29.05% inhibition rate at a concentration of 100 μM [1].
T36336 Burnettramic Acid A
Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0....
T36706 Bottromycin A2
Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isola...
T7582 Tafamidis meglumine Fx-1006A Others
Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade
T4565 Tafamidis Fx-1006A Others
Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR di...
T9447 AG-10 Acoramidis Others
AG-10 (Acoramidis) is an orally active and selective kinetic stabilizer of TTR (transthyretin). AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis.
T39740 Acoramidis hydrochloride AG10 hydrochloride,Alxn2060 hydrochloride Others
Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis.
T15116 Dichlorophenyl-ABA Others
Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.
T74645 Eplontersen
Eplontersen, a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide, targets transthyretin (TTR) mRNA to suppress the synthesis of both variant and wild-type TTR proteins. The accumulatio...
T38909 Inotersen sodium ISIS-420915 sodium
Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, ...
TMIH-0549 Tafamidis-d3
Tafamidis-d3 is a deuterated compound of Tafamidis. Tafamidis has a CAS number of 594839-88-0. Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds...
T38918 Revusiran ALN-TTRSC
Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA. It is utilized in TTR-mediated amyloidosis research.
T71785 GUN35758
GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. Thi...
T38804 Patisiran sodium
Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthes...
T79417 PITB
PITB, a selective and orally active transthyretin (TTR) aggregation inhibitor, is utilized in transthyretin amyloidosis (ATTR) disease research [1].
T39304 Vutrisiran ALN-TTRsc02
Vutrisiran (ALN-TTRsc02) is an investigational, liver-directed small interfering ribonucleic acid (siRNA) compound designed for research on transthyretin (TTR)-mediated amyloidosis.
T61423 Transthyretin-IN-1
Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T62141 RBP4 ligand-1
RBP4 ligand-1 is a non-retinoid ligand for retinol-binding protein 4 (RBP4). hRBP4SPAIC50 and RBP4-TTR FRET IC50 values were 0.23±0.11 and 0.13±0.12 μM for the radioligand binding assay and FRET assay, respectively. 0.12...
Cat No. Product Name Synonyms Targets
T36337 Burnettramic Acid A aglycone
Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neona...
T4S1637 Gamma-Mangostin Normangostin Others , 5-HT Receptor
1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...

Natural Products

Burnettramic Acid A aglycone
T36337
Synonym:
Target:
gamma-Mangostin
T4S1637
Synonym: Normangostin
Target: Others, 5-HT Receptor

Recombinant Proteins

Species：
Cynomolgus (1)
Human (1)
Expression System：
HEK293 Cells (2)
Tag：
C-His (1)
N-His (1)
Cat No. Product Name Species Expression System
TMPK-01090 Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in th...
TMPY-00261 Meprin beta Protein, Human, Recombinant (His) Human HEK293 Cells
MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the me...
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