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Dichlorophenyl-ABA

Catalog No. T15116 CAS 18201-65-5

Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.

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Dichlorophenyl-ABA, CAS 18201-65-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,300.00
50 mg	6-8 weeks	$ 1,690.00
100 mg	6-8 weeks	$ 2,500.00

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Biological Description

Chemical Properties

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Description

Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.

In vitro

Dichlorophenyl-ABA can prevent L55P aggregate formation in the conditioned medium. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP). However, it needs to undergo further stages of drug development to overcome its toxicity.

Molecular Weight	282.12
Formula	C13H9Cl2NO2
CAS No.	18201-65-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cardoso I, et al. Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design. Biochem J. 2007 Nov 15;408(1):131-8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dichlorophenyl-ABA 18201-65-5 Others Dichlorophenyl ABA DichlorophenylABA inhibitor inhibit

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