5
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1926 | Sonidegib | Erismodegib,NVP-LDE225,LDE225 | Hedgehog/Smoothened , Smo |
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | |||
T15727 | Sonidegib diphosphate | NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate | Smo |
Sonidegib diphosphate (LDE225 diphosphate) is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively). | |||
T20723 | LGE-899 | Sonidegib metabolite M48,LGE 899 | Drug Metabolite |
LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib. | |||
T70178 | Sonidegib metabolite M25 | ||
Sonidegib metabolite M25 is a smoothened (SMO) antagonist. | |||
T32828 | LNC-119 | Sonidegib metabolite M16,LNC119 | |
LNC-119 is an aminosteroid. |