smac — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T81148	Smac-based peptide
	Smac-based peptide, a biologically active peptide derived from SMAC that interacts with the BIR3 domain, exhibits specific biological functions.
T6763	Xevinapant	ARRY-334543,SM-406,AT406,Debio-1143	IAP
	Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, ...		IAP
T3299	Xevinapant hydrochloride	AT-406 HCl,SM-406	Apoptosis , IAP
	Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66....		Apoptosis , IAP
T20053	Jasmacyclen	EC 226-501-6,NSC-6598,Verdyl acetate,Greenyl acetate,NS 6598,NSC 6598
	Jasmacyclen is a compound in which has an aroma.
T35205	Xylosmacin
	Xylosmacin is a biochemical.
T2080	LCL161		IAP
	LCL161, a SMAC mimetic, effectivity binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).		IAP
T6007	Birinapant	TL32711	Apoptosis , IAP , HIV Protease
	Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with po...		Apoptosis , IAP , HIV Protease
T12932L	SM-164		Apoptosis , IAP
	SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.		Apoptosis , IAP
T26242	SW IV-52	SW-IV-52,SW IV52,SW IV 52,SWIV52
	SW IV-52 is an XIAP-inhibitor that acts as a second mitochondria-derived activator of caspases (SMAC) mimetic.
T63969	SM-433
	SM-433 is a Smac mimetic and inhibitor of inhibitors of apoptosis (IAPs). SM-433 has a strong affinity for XIAP BIR3 protein (IC50 <1 μM).
T64217	SM-433 hydrochloride
	SM-433 hydrochlorid is a Smac mimetic, an inhibitor of inhibitory apoptosis proteins (IAPs). SM-433 hydrochlorid is able to bind XIAP BIR3 protein with a potent IC50 <1 μM.
T15723	LBW242		Others
	LBW242 is a 3-mer and Smac mimetic and is an effective and orally active proapoptotic IAP inhibitor. LBW242 has activity against multiple myeloma and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian ...		Others
T75243	SM-164 Hydrochloride
	SM-164 Hydrochloride, a cell-permeable Smac mimetic compound, exhibits high affinity for the XIAP protein, specifically targeting both the BIR2 and BIR3 domains, with an IC50 value of 1.39 nM. This action categorizes it ...
T38857	SBP-0636457	SBI-0636457,SB1-0636457,SBP-0636457
	SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for ...
T12932	SM-164 Hydrochloride (957135-43-2 free base)	SM-164 Hydrochloride	IAP
	SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and functions as an extremely potent antagonist of XIAP.		IAP
T36201	AZD5582 dihydrochloride	AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to ...
T69323	Dexamethasone sodium succinate
	Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), i...
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and t...