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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1537 | Rapamycin | Sirolimus,AY 22989,NSC-2260804 | Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal |
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy. | |||
T12691 | Rapamycin-d3 | AY-22989-d3,Sirolimus-d3 | Others |
Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells). | |||
T2145 | Temsirolimus | NSC 683864,CCI-779 | Apoptosis , mTOR , Autophagy |
Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer. | |||
T26309 | Umirolimus | Biolimus-A9,TRM-986,TRM 986,TRM986,Biolimus A9 | |
Umirolimus is a sirolimus derivative from a biodegradable polylactic acid polymer. It has enhanced anti-inflammatory and antiproliferative activity with an improved pharmacokinetic profile. |