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Search Results for " smad4 "

Targets

3

Compounds

9

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T1748 Kartogenin KGN TGF-beta/Smad
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
T78798 MY-673
MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 protein expression in the TGF-β/SMAD pathway. This compound effecti...
T71252 PC-046
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01108 SMAD4 Protein, Human, Recombinant (His) Human E. coli
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric...
TMPH-02055 RBPMS Protein, Human, Recombinant (His & Myc) Human E. coli
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 an...
TMPJ-00271 SMAD3 Protein, Human, Recombinant (His & Flag) Human E. coli
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so...
TMPH-01699 SMAD2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in t...
TMPH-01702 SMAD6 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPY-02444 ATF2 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-ac...
TMPY-03291 SMAD2 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus Insect Cells
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD...
TMPY-03419 SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST) Human,Mouse,Rat Baculovirus Insect Cells
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is...
TMPY-04468 STK16 Protein, Human, Recombinant (His & NusA) Human E. coli
Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is...
Cat No. Product Name
L4100 TGF-beta/Smad Compound Library

184 compounds
A unique collection of 184 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
TargetMol