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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7344 | SDMA | NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine | Endogenous Metabolite |
SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD). | |||
T9575 | MRTX9768 | Histone Methyltransferase | |
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. | |||
T40254 | MRTX-1719 | Histone Methyltransferase | |
MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells. | |||
T36630 | MRTX9768 hydrochloride | ||
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT... |