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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21675 | SB 203580 hydrochloride | ||
Adezmapimod (SB 203580) hydrochloride is a selective ATP-competitive inhibitor of p38 MAPK, displaying IC50 values of 50 nM for SAPK2a/p38 and 500 nM for SAPK2b/p38β2. This compound also inhibits LCK, GSK3β, and PKBα, al... | |||
T1764 | Adezmapimod | PB 203580,RWJ 64809,SB203580 | Mitophagy , p38 MAPK , Autophagy |
Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100... | |||
T6335 | Tie2 kinase inhibitor 1 | Tie2 kinase inhibitor | Tie-2 |
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 μM, which is 200-fold more effective than p38. |