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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0349 | Riluzole | PK 26124,RP-54274 | GABA Receptor , Sodium Channel , NMDAR |
Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. | |||
T37608 | Riluzole-13C,15N2 | Riluzole-13C,15N2 | |
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic... | |||
T41265 | Riluzole hydrochloride | ||
Riluzole hydrochloride, a use-dependent Na+ channel blocker with anticonvulsant properties, belongs to a category of drugs that also inhibit GABA uptake, exhibiting an inhibitory concentration 50 (IC50) of 43 μM. | |||
T35919 | N-hydroxy Riluzole | ||
N-hydroxy Riluzole is a metabolite of the antiglutamatergic agent riluzole .1It is formed from riluzole predominantly by the cytochrome P450 (CYP) isoform CYP1A2 in human hepatic microsomes. 1.Sanderink, G.J., Bournique,... | |||
T17174 | Troriluzole | BHV-4157 | Others |
Troriluzole is an orally active glutamate modulator. Troriluzole reduces the synaptic glutamate level and increases synaptic glutamate absorption. | |||
T80626 | VGSCs-IN-1 | Sodium Channel | |
VGSCs-IN-1 is a potent VGSC inhibitor, a 2-piperazine analog of Riluzole that exhibits good blocking activity on Nav1.4.VGSCs-IN-1 can be used to study cellular excitability disorders. |