2
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2399 | Bortezomib | Radiciol,NSC 681239,MG 341,DPBA,Brotezamide,LDP 341 | Apoptosis , NF-κB , Proteasome , Autophagy |
Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective. Bortezomib has antitumor activity and inhibits NF-κB, which can disrupt the cell cycle and induce apoptosis. | |||
T37581 | SCIO 469 hydrochloride | ||
Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylati... |