prmt5-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12541	PRMT5-IN-1		Histone Methyltransferase
	PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).		Histone Methyltransferase
T62815	PRMT5-IN-1 hydrochloride
	PRMT5 IN-1 hydrochloride (compound 9) is a hemiacetalamine, a potent inhibitor of the selective protein arginine methyltransferase 5 (PRMT5) with an inhibitory effect on PRMT5/MEP50 (IC50: 11 nM). PRMT5 IN-1 hydrochlorid...
T39008	PRMT5-IN-4	PRMT5-IN-4
	PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.
T61986	PRMT5-IN-21
	PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.
T61862	PRMT5-IN-19
	PRMT5-IN-19 (Compound 41) is a potent orally active PRMT5 inhibitor, exhibiting selectivity towards the SAM-binding pocket of PRMT5 with IC50 values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay)....
T78152	PRMT5-IN-25		Histone Methyltransferase
	PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1].		Histone Methyltransferase
T78172	PRMT5-IN-29		Histone Methyltransferase
	PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].		Histone Methyltransferase
T76414	PRMT5-IN-23
	PRMT5-IN-23 (compound 50), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a novel anti-tumor target associated with epigenetic modification, PRMT5 belongs to the protein ar...
T76413	PRMT5-IN-22
	PRMT5-IN-22 (compound 53), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a protein arginine methyltransferase, PRMT5 represents a novel anti-tumor target associated with e...
T36630	MRTX9768 hydrochloride
	MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT...
T79274	PRMT5-IN-31		Histone Methyltransferase
	PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and establishing key interactions with amino acid residues. It exhibits a...		Histone Methyltransferase
T79035	PRMT5-IN-28		Histone Methyltransferase
	PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes including gene transcription, mRNA splicing, DNA repair, prot...		Histone Methyltransferase
T79873	TNG-462		Histone Methyltransferase
	TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1].		Histone Methyltransferase
T79275	Antiproliferative agent-25		Histone Methyltransferase
	Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM. It elevates hnRNP E1 protein levels and forms hydrogen bond interactions with SAM and the E444 residue of PRMT5. Thi...		Histone Methyltransferase