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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T23150 | PHGDH-inactive | Others | |
inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503 | |||
T73143 | PHGDH-IN-3 | Dehydrogenase | |
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about cancer. | |||
T62232 | PHGDH-IN-2 | ||
PHGDH-IN-2 is a potent inhibitor of NAD+-competitive PHGDH (IC50: 5.2 μM). PHGDH-IN-2 exhibits inhibitory effects on the growth of PHGDH-dependent cancer cells and inhibits the serine synthesis pathway in MDA-MB-468 cell... | |||
T4213 | NCT-503 | NCT 503 | Dehydrogenase , FLT , TAM Receptor |
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells. | |||
T16277 | NCT-502 | N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide | Dehydrogenase |
NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-d... | |||
T14884 | CBR-5884 | Others , Dehydrogenase | |
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with h... | |||
T31557 | DNS-pE | DNSpE,DNS pE | |
DNS-pE is the first small molecule that can selectively label endogenous 3-phosphoglycerate dehydrogenase (PHGDH) from various mammalian cells. | |||
T28425 | PKUMDL-WQ-2201 | ||
PKUMDL-WQ-2201 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with Anti-tumor Activity, it binds to site II. | |||
T14564 | BI-4924 | Others | |
BI-4924 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH) (IC50=3 nM). It has excellent Microsomal and hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis at 72 h ( IC50: 2200 nM... |