phd2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T81495	PhD2
	PhD2, an antimicrobial peptide originating from monkey leukocytes, exhibits efficacy against bacteria and the fungus Candida albicans [1].
T79241	PHD2-IN-1		HIF/HIF Prolyl-Hydroxylase
	PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].		HIF/HIF Prolyl-Hydroxylase
T62298	PHD2/HDACs-IN-1
	PHD2/HDACs-IN-1 is a potent mixed inhibitor of PHD2/HDACs, acting on PHD2 (IC50: 1.15 μM), HDAC1 (IC50: 19.75 μM), HDAC2 (IC50: 26.60 μM), HDAC16 (IC50: 15.98 μM). HDACs-IN-1 is a low toxicity nephroprotective agent that...
T22022	Adaptaquin		HIF
	Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].		HIF
T2445	FG-2216	YM-311,FG2216,FG 2216	HIF/HIF Prolyl-Hydroxylase
	FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.		HIF/HIF Prolyl-Hydroxylase
T7880	IOX4		HIF/HIF Prolyl-Hydroxylase
	IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)		HIF/HIF Prolyl-Hydroxylase
T5392	TP0463518		HIF/HIF Prolyl-Hydroxylase
	TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).		HIF/HIF Prolyl-Hydroxylase
T4106	MK-8617	MK8617	HIF/HIF Prolyl-Hydroxylase
	MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).		HIF/HIF Prolyl-Hydroxylase
T1823	IOX2	IOX 2,JICL38	HIF/HIF Prolyl-Hydroxylase
	IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).		HIF/HIF Prolyl-Hydroxylase
T3180	JNJ-42041935	HIF-PHD Inhibitor II	HIF/HIF Prolyl-Hydroxylase
	JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.		HIF/HIF Prolyl-Hydroxylase
T26880	BNS
	BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.
T39040	HIF-PHD-IN-1
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therap...
T79797	PHD-IN-1		HIF/HIF Prolyl-Hydroxylase
	PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM. It demonstrates EC50 values of 2.5 μM in EPO Elisa assays within both Caco2-HIF1a-HiBiT-clone-1 and Hep3B cell lines [1].		HIF/HIF Prolyl-Hydroxylase
T61458	HIF-PHD-IN-2
	HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].
T68511	KRH102140
	KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH10214...
T37198	Ethyl LipotF
	Selective FTO inhibitor (IC50 = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N6-methyladenosine (m6A) in HeLa cells in ...