pcsk9 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T67776	PCSK9-IN-11		Others
	PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein l...		Others
T72025	PCSK9-IN-10		Serine/threonin kinase
	PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Li...		Serine/threonin kinase
T39528	PCSK9-IN-2	PCSK9-IN-2
	PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.
T64362	AZD0780	PCSK9-IN-12,EX-A6975	Others
	AZD0780 (EX-A6975) exhibits bind affinity for PCSK9 ( Kd ＜200 nM). AZD0780 has research value in cholesterol metabolism.		Others
T39685	PCSK9 degrader 1
	PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T13813	PCSK9 ligand 1		Others
	PCSK9 ligand 1 is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9(Ki of 107 nM).		Others
T75147	PCSK9-IN-18
	PCSK9-IN-18 (compound 188) is a potent PCSK9 inhibitor with a K D value of <200 nM [1] .
T73008	PCSK9-IN-13
	PCSK9-IN-13 is a potent inhibitor of PCSK9, effectively preventing the binding of PCSK9 to low-density lipoprotein (LDL) receptors through its mechanism of action. It exhibits this inhibitory activity with an IC 50 value...
T75545	PCSK9-IN-9
	PCSK9-IN-9, a natural isocoumarin, inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression, demonstrating specificity by inhibiting PCSK9 with an IC50 value of 11.9 μM [1].
T81535	PCSK9-IN-20
	PCSK9-IN-20 (Compound 3i) is a PCSK9 inhibitor exhibiting an IC50 value of 3.96 µM, shown to reduce PCSK9 and enhance LDLR protein levels in vitro [1].
T74167	PCSK9-IN-3
	PCSK9-IN-3 is a next-generation tricyclic peptide inhibitor of PCSK9, characterized by its novel structure, high potency, and oral bioavailability.
T60764	PCSK9 modulator-4
	PCSK9 modulator-4 (Compound 21) can be used in hyperlipidemia research that is a potent PCSK9 modulator (EC 50 = 0.15 nM). PCSK9 is a lowering low-density lipoprotein cholesterol (LDL-C) target that is recently validated...
T60646	PCSK9 modulator-3
	PCSK9 modulator-3 (Compound 13) is a potent PCSK9 modulator with an EC 50 value of 2.46 nM that has the potential in the hyperlipidemia research. PCSK9 is a recently proved target for lowering low-density lipoprotein cho...
T79051	PCSK9-IN-15
	PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, K D <200 nM) that plays a crucial role in cholesterol metabolism by regulating blood levels of low-density lipoprotein ch...
T79030	PCSK9-IN-14
	PCSK9-IN-14, also known as compound Ia-8, is a potent inhibitor of PCSK9 [1].
T79053	PCSK9-IN-17
	PCSK9-IN-17 is a PCSK9 inhibitor utilized in the research of cholesterol metabolism.
T60541	PCSK9 modulator-2
	PCSK9 modulator-2 (Compound 1) is a potent PCSK9 modulator (EC 50 = 202 nM) that has the potential to be used in hyperlipidemia research. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a recently validated ther...
T79239	PCSK9-IN-19
	PCSK9-IN-19 (Compound 1), a PCSK9 inhibitor, is utilized in researching the treatment of high LDL-cholesterol levels and the prevention of coronary artery disease [1].
T79052	PCSK9-IN-16
	PCSK9-IN-16, holds potential for research into hypercholesterolemia and other cardiovascular diseases [1].
TN2082	Pinostrobin		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF