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Search Results for " p450s "

6

Compounds

Cat No. Product Name Synonyms Targets
TN6848 Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid P450
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid selectively inactivate the CYP73...
T5S2343 Acetylshikonin Acetyl shikonin Others , P450 , AChE
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...
T24988 7ETMC 7 ETMC,7-ETMC
7ETMC is a selective Human Cytochrome P450s 1A1 and 1A2 inhibitor. 7ETMC showed IC50s of 0.46 μM and 0.50 μM for P450s 1A1 and 1A2 in the first six minutes, respectively, and did not show any inhibition activity for P450...
TN3627 Chalepensin ATPase , NADPH-oxidase , P450 , Antifection
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential drug interaction through mechanism-based inhibition. Chalepe...
T37926 7-Ethoxy-4-(trifluoromethyl)coumarin
7-Ethoxy-5-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1Upon O-deethylation by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quanti...
T35712 Debutyldronedarone hydrochloride SR35021 hydrochloride
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbut...
TargetMol