13
2
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T81441 | PLK1/p38γ-IN-1 | p38 MAPK | |
PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular carcinoma and hepatoblastoma cell lines in vitro [1]. | |||
T6089 | Neflamapimod | VX-745 | p38 MAPK , Autophagy |
Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ. | |||
T16812 | RWJ-67657 | JNJ 3026582 | p38 MAPK |
RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect. | |||
T6927 | Pamapimod | R1503,Ro4402257 | p38 MAPK , Autophagy |
Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv... | |||
T10298 | AMG-548 hydrochloride (864249-60-5 free base) | AMG-548 hydrochloride | p38 MAPK |
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibi... | |||
T10298L | AMG-548 | p38 MAPK | |
AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole b... | |||
T18682 | SJFδ | Others | |
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1]. | |||
T10298L2 | AMG-548 dihydrochloride (864249-60-5 free base) | AMG-548 dihydrochloride | p38 MAPK |
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhi... | |||
T70638 | P38-α MAPK-IN-5 | ||
P38-α MAPK-IN-5 is a potent inhibitor of p38α, demonstrating inhibitory concentrations (IC50) of 0.1 nM for p38α, 0.2 nM for p38β, 944 nM for p38γ, and 4100 nM for p38δ. It exhibits anti-inflammatory properties and holds... | |||
T36260 | NR 7h | ||
Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-d... | |||
T63762 | AMG-548 dihydrochloride | ||
AMG-548 dihydrochloride is a selective, orally active p38α inhibitor with a Ki value of 0.5 nM, a slight selectivity for p38β (Ki=36 nM) and >1000-fold selectivity for p38γ and p38δ. AMG-548 dihydrochloride exhibits inhi... | |||
T63371 | AMG-548 hydrochloride | ||
AMG-548 hydrochloride is a selective, orally active p38α inhibitor with a Ki value of 0.5 nM, a slight selectivity for p38β (Ki=36 nM) and a 1000-fold selectivity for p38γ and p38δ. AMG 548 hydrochloride also effectively... | |||
T68321 | AS1940477 | ||
AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blo... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04430 | P38 gamma/MAPK12 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t... | |||
TMPY-04429 | P38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t... |