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Search Results for " ntrk1 "

Targets

4

Compounds

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T22318 Taletrectinib DS-6051b,AB-106 Trk receptor , ROS , ROS Kinase
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.
T38995 Taletrectinib free base AB-106freebase,Taletrectinib free base,IBI-344 free base,DS-6051b free base ROS Kinase
Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s...
T62531 TRK-IN-12
TRK-IN-12 (Compound 9e), a macrocyclic derivative, is a potent TRK inhibitor, with efficacy against TRK G595R (IC 50 = 13.1 nM). It demonstrates significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (I...
T79706 TRK-IN-24 Trk receptor
TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, resp...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00774 TrkA Protein, Human, Recombinant (aa 33-417, His) Human HEK293 Cells
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signa...
TMPH-02878 PTPRS Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects...
TargetMol