ns3/4a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22394	Paritaprevir	ABT450,ABT-450,Veruprevir	HCV Protease
	Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively.		HCV Protease
T5938	4-Phenoxybenzylamine		HCV Protease
	4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .		HCV Protease
T6190	Telaprevir	VX-950,LY-570310,Incivek,MP-424	HCV Protease , SARS-CoV
	Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).		HCV Protease , SARS-CoV
T5126	Glecaprevir	ABT-493	HCV Protease , SARS-CoV
	Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).		HCV Protease , SARS-CoV
T4197	HZ-1157	HZ1157,DHFR-inhibitor	HCV Protease
	HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.		HCV Protease
T6025	Danoprevir	R7227,ITMN-191,RG7227,RO5190591	HCV Protease , SARS-CoV
	Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).		HCV Protease , SARS-CoV
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T4547	Grazoprevir	MK-5172	HCV Protease , SARS-CoV
	Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.08 nM (gt2a), 0.90 nM (gt3a), 0.01 nM (gt1b), ...		HCV Protease , SARS-CoV
T19862	Voxilaprevir		HCV Protease
	Voxilaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease.		HCV Protease
T3226	Paritaprevir	ABT-450,Veruprevir	HCV Protease
	Paritaprevir (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity again...		HCV Protease
T8675	Vaniprevir		Others
	Vaniprevir is a macrocyclic hepatitis C virus NS3/4a protease inhibitor and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir has good plasma exposure and excellent liver exposure...		Others
T71031	Deldeprevir Na
	Deldeprevir Na is an Antiviral Polyprotein cleavage inhibitor. HCV NS3/4A inhibitor.
T70655	Furaprevir
	Furaprevir is an HCV NS3/4A Inhibitor
T11540	HCV-IN-3		Others
	HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor (IC50: 20 μM; Kd: 29 μM).		Others
T68354	Danoprevir sodium
	Danoprevir sodium is an NS3/4A protease inhibitor used in the treatment of Hepatitis C
T68335	MK-1220
	MK-1220 is a novel Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
T12065	Grazoprevir sodium salt	MK-5172 (sodium salt)	Others
	Grazoprevir sodium salt is a selective Hepatitis C virus NS3/4a protease inhibitor with broad activity across genotypes and resistant variants.		Others
T19948	Grazoprevir potassium salt	MK 5172 potassium,Grazoprevir,Grazoprevir potassium,MK 5172,MK5172,MK-5172
	Grazoprevir is a drug approved for the treatment of hepatitis C. Grazoprevir is a second-generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets.
T21456	Grazoprevir hydrate	Grazoprevir,MK5172,MK 5172,MK-5172
	Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to ...
T73898	Paritaprevir dihydrate
	Paritaprevir dihydrate (ABT-450), a highly effective and orally administered antiviral, acts as a non-structural protein 3/4A (NS3/4A) protease inhibitor, displaying EC50 values of 1 and 0.21 nM against HCV genotypes 1a ...