5
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7791 | Iberdomide | CC-220 | Apoptosis , Ligand for E3 Ligase |
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay). | |||
T74428 | Biotinylated-JQ1 | ||
Biotinylated-JQ1 (Biotin-JQ1), a biotinylated derivative of JQ1, selectively binds to the BRD4 bromodomain with high affinity. It effectively inhibits the proliferation of MM1.S multiple myeloma cells, demonstrating an E... | |||
T77920 | ZXH-4-130 TFA | PROTACs | |
ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN. At a concentration of 10 nM in MM1.S cells, ZXH-4-130 TFA achieves approximately 80% degradation o... | |||
T63010 | ZXH-1-161 | ||
ZXH-1-161 is a potent regulator of cereblon (CRBN) that acts on wild-type MM1.S cells (IC50: 39 μM). ZXH-1-161 selectively degrades GSPT1. ZXH-1-161 can be used to study multiple myeloma. | |||
T2558 | Cladribine | 2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA | Apoptosis , Adenosine deaminase |
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases. |