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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4295 | (R)-GNE-140 | GNE-140 | Dehydrogenase |
(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. | |||
T11829 | LDH-IN-1 | Dehydrogenase | |
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively). | |||
T15435 | GSK2837808A | Dehydrogenase | |
GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively). | |||
T22336 | Galloflavin | Dehydrogenase | |
Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent. | |||
T61539 | AXKO-0046 | ||
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor. | |||
T81747 | MS6105 | PROTACs | |
MS6105 is a chimeric LDH protein hydrolysis-targeted PROTAC that degrades LDHA and LDHB efficiently, with its activity contingent on both time and the ubiquitin-proteasome system, exhibiting anticancer properties [1]. Ad... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00797 | LDHB Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LD... |