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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T79079 | JAK1-IN-11 | JAK | |
JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations with IC50 values of 0.02 nM (JAK1) and 0.44 nM (JAK2), demonstrating high selectivity for JAK1 over J... | |||
T1849 | Momelotinib | CYT11387,CYT387,LM-1149 | Apoptosis , JAK , Autophagy |
Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhib... | |||
T2636 | Decernotinib | VX-509,VRT-831509 | Tyrosine Kinases , JAK |
Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. | |||
T61658 | TYK2-IN-11 | ||
TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advanc... |