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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14369 | AZD-0284 | ROR | |
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. | |||
T76901 | Afasevikumab | ||
Afasevikumab (RG 7624; RO 5553110; NI-1401), a fully human monoclonal IgG1κ antibody, neutralizes both IL-17A and IL-17F, exhibiting anti-inflammatory activities [1]. | |||
T76798 | Bimekizumab | ||
Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody), a humanized monoclonal antibody, selectively neutralizes IL-17A and IL-17F, both of which promote osteogenic differentiation in human periosteum-derived cells (... | |||
T79024 | Androgen receptor-IN-5 | Androgen Receptor | |
Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties. It additionally suppresses the synthesis of IL-17A, IL-17F, and INF-γ. | |||
T76885 | Sonelokimab | ||
Sonelokimab (ALX 0761; M 1095) is a trivalent nanobody that combines monovalent camelid-derived nanobodies targeting human interleukin (IL)-17A and IL-17F, along with human serum albumin VHHs. This composition presents s... | |||
T13172L | TMP778 | Others | |
TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay). |