hdac6 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T69753	HDAC6 degrader 9c		HDAC
	HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.		HDAC
T36625	LSD1/HDAC6-IN-1	LSD1/HDAC6-IN-1
	LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity ...
T1983	CAY10603	HDAC6 Inhibitor,BML-281	HDAC
	CAY10603 (BML-281) is a potent and selective inhibitor of HDAC6.		HDAC
T22159	TCS HDAC6 20b
	TCS HDAC6 20b is a HDAC6 -selective inhibitor that blocks the growth of estrogen receptor α-positive breast cancer MCF-7 cells [1].
T79769	HDAC6-IN-23		HDAC
	HDAC6-IN-23 (compound 9), an orally active inhibitor of HDAC6 [1], displays selective enzymatic inhibition.		HDAC
T82224	HDAC6-IN-25		HDAC
	HDAC6-IN-25 (compound 8) is a potent and selective HDAC6 inhibitor, exhibiting an IC50 value of 0.6 nM [1].		HDAC
T73043	HDAC6-IN-15
	HDAC6-IN-15, a selective histone deacetylase 6 (HDAC6) inhibitor, exhibits potent inhibitory activity with an IC50 value of 38.2 nM, making it valuable for research in cancer and neurodegenerative diseases.
T78839	HDAC6-IN-19		HDAC
	HDAC6-IN-19 (Compound 14g), an HDAC6 inhibitor with an IC50 of 2.68 nM, additionally inhibits HDAC1, HDAC2, and HDAC3, with IC50 values of 61.6 nM, 98.7 nM, and 103 nM, respectively. This compound effectively suppresses ...		HDAC
T74617	HDAC6-IN-8		HDAC
	Compound 12C, modified by altering cap groups, exhibits broad-spectrum enzyme inhibitory activity, as demonstrated in enzyme inhibition assays. Conversely, compounds 9m and 9q display a predilection towards HDAC6 inhibit...		HDAC
T82225	HDAC6-IN-24		HDAC
	HDAC6-IN-24 (compound N1) is an inhibitor of histone deacetylase 6 (HDAC6) [1].		HDAC
T61792	HDAC6-IN-10
	HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Fu...
T82226	HDAC6-IN-21		HDAC
	HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].		HDAC
T63472	HDAC6-IN-4
	HDAC6-IN-4 (C10) is an orally active, highly selective, potent and non-significantly toxic HDAC6 inhibitor (IC50: 23 nM). HDAC6-IN-4 induces apoptosis and exhibits potent anti-tumor effects.
T60954	HDAC6-IN-6
	HDAC6-IN-6 (compound 6a) is a potent inhibitor of HDAC6 that can penetrate BBB with an IC50 value of 0.025 μM. HDAC6-IN-6 has potent inhibitory activity against AChE and Aβ 1-42 self-aggregation with IC50 values of 0.72 ...
T77922	HDAC6 degrader-1		PROTACs
	HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linker, and an E3 ligase recruiting ligand. This compound effect...		PROTACs
T63247	HDAC6-IN-12
	HDAC6-IN-12 is a potent inhibitor of HDAC6 that binds in the DNA chain, causing DNA damage and exhibiting anticancer effects that can be used in cancer research.
T79523	HDAC6-IN-18		HDAC
	HDAC6-IN-18 (Compound 4), an irreversible and selective HDAC6 isoform inhibitor, exhibits potent anti-multiple myeloma effects. It demonstrates HDAC6 inhibitory activity with IC50 values of 0.17, 0.7, and 0.42 μM in RPMI...		HDAC
T61474	HDAC6-IN-13
	HDAC6-IN-13 (Compound 35m) is a potent and highly selective orally active inhibitor of HDAC6, with an IC50 of 0.019 μM. It also demonstrates inhibitory activity against HDAC1, HDAC2, and HDAC3, with IC50 values of 1.53 μ...
T75018	HDAC6 degrader-3
	HDAC6 degrader-3, a selective and potent degrader of HDAC6 through ternary complex formation and the ubiquitin-proteasome pathway, exhibits a DC50 value of 19.4 nM. With IC50 values of 4.54 nM for HDAC6 and 0.647 μM for ...
T78769	HDAC6-IN-17		HDAC
	HDAC6-IN-17 (compound 5b) is a potent inhibitor of HDAC6, exhibiting IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4. It demonstrates cytotoxic activity against human cancer cell lines and is ut...		HDAC