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Cat No. | Product Name | Synonyms | Targets |
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T72626 | A2AR-antagonist-1 | Adenosine Receptor | |
A2AR-antagonist-1 (compound 38), an orally active adenosine A2A receptor antagonist with an IC50 value of 29 nM, demonstrates anti-tumor properties and stability in mouse liver microsomes (t1/2 = 86.1 min). Additionally,... | |||
T71890 | F5446 | ||
F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby ... |
Cat No. | Product Name | Species | Expression System |
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TMPY-00817 | Granzyme B/GZMB Protein, Human, Recombinant (His) | Human | HEK293 |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the ... | |||
TMPJ-00770 | Granzyme B/GZMB Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an... | |||
TMPY-00818 | Granzyme H/GZMH Protein, Human, Recombinant (His) | Human | HEK293 |
Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes... | |||
TMPH-01057 | Caspase-8 Protein, Human, Recombinant (His) | Human | E. coli |
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood... |