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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1929 | Filgotinib | GLPG0634 | Tyrosine Kinases , JAK |
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively. | |||
T63815 | Filgotinib maleate | ||
Filgotinib (maleate) is a selective, orally active JAK1 inhibitor that effectively inhibits the activity of JAK1 (IC50: 10 nM), JAK2 (IC50: 28 nM), JAK3 (IC50: 810 nM) and TYK2 (IC50: 116 nM). maleate) can be used to stu... | |||
T70472 | Filgotinib HCl hydrate | ||
Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease. | |||
T70471 | Cgs 26303 | ||
Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation. | |||
T67905 | GS-829845 | JAK , Drug Metabolite | |
GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent. |