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Search Results for " f508del "

11

Compounds

Cat No. Product Name Synonyms Targets
T9499 Icenticaftor QBW251 CFTR
Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.
T2595 Lumacaftor VX-809,VRT 826809 CFTR , Autophagy
Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T2588 Ivacaftor Ivacaftor (VX-770),VX-770 CFTR , Autophagy
Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T7083 GLPG1837 ABBV-974 CFTR , Autophagy
GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T3135 KM11060 CFTR , Autophagy
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.
T30293 Bamocaftor VX-659 CFTR
Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of c...
T5312 CFTR corrector 2 FDL169 CFTR , Autophagy
CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.
T35883 RNF5 inhibitor inh-02 RNF5 inhibitor inh-02
RNF5 inhibitor inh-02, a potent E3 ubiquitin ligase RNF5/RMA1 inhibitor, demonstrates significant efficacy in rescuing F508del-CFTR with an EC50 of 2.2 uM in bronchial epithelial cells homozygous for the F508del mutation...
T13705 GLPG2451 Cysteine Protease
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).
T75230 (Rac)-Tezacaftor
(Rac)-Tezacaftor ((Rac)-VX-661) is a racemic mixture of the F508del CFTR corrector, Tezacaftor. It is utilized in cystic fibrosis research [1].
T37564 C4 Ceramide (d18:1/4:0) C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)
C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used...
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