dpre1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4044	DprE1-IN-2		Antibacterial , DprE1
	DprE1-IN-2 is an effective DprE1 inhibitor.		Antibacterial , DprE1
T3224	TBA-7371	AZ 7371,DprE1-IN-1	Antibacterial , PDE , DprE1
	TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6.		Antibacterial , PDE , DprE1
T27206	DprE1-IN-377790
	DprE1-IN-377790 is a novel DprE1 inhibitor, killing M. tuberculosis.
T79440	DprE1-IN-5
	DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates antimycobacterial efficacy against drug-resistant strains. Additionally, it ...
T62741	DprE1-IN-1
	DprE1-IN-1 is a potent, orally active DprE1 inhibitor that exhibits good hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 has good anti-branched bacilli activity in macrophages, reducing...
T62147	DprE1-IN-4
	DprE1-IN-4 is a potent, non-covalent inhibitor of DprE1 (IC50: 0.90 μg/mL). DprE1-IN-4 has acceptable pharmacokinetic properties and has a significant bactericidal effect in a mouse model of acute tuberculosis.
T78883	DprE1-IN-9
	DprE1-IN-9 (compound B18) is an efficient reversible inhibitor of DprE1, interacting with the enzyme's receptor cavity. It exhibits potent antimycobacterial properties, demonstrating activity against both non-pathogenic ...
T79442	DprE1-IN-7
	DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM against the Mtb H37Rv strain. It exhibits antimycobacterial effect...
T79628	DprE1-IN-8		Antibiotic
	DprE1-IN-8 is a potent inhibitor of DprE1, exhibiting an IC50 of less than 0.75 μM. It has demonstrated significant activity against Mtb H37Rv, with an IC50 value of 6 nM, making it applicable in tuberculosis research [1...		Antibiotic
T79441	DprE1-IN-6
	DprE1-IN-6 (Compound 56) is a DprE1 inhibitor with demonstrated anti-TB activity, exhibiting a minimum inhibitory concentration (MIC) of 1 μM against the Mtb H37Rv strain, along with efficacy against drug-resistant mycob...
T3583	Macozinone	PBTZ169	Antibacterial , DprE1
	Macozinone (PBTZ169) inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043.		Antibacterial , DprE1
T5315	TCA1	TCA-1,TCA 1	Antibacterial , Antibiotic
	TCA1 (TCA 1) is a small molecule with activity against drug-resistant and persistent tuberculosis.		Antibacterial , Antibiotic
T3582	BTZ043		Antibacterial , Antibiotic , DprE1
	BTZ043 is a DprE1 inhibitor with nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.		Antibacterial , Antibiotic , DprE1
T6425	BTZ043 Racemate	BTZ044,BTZ10526038,Benzothiazinone 10526038	Antibacterial , DprE1
	BTZ043 Racemate (Benzothiazinone 10526038) is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor, used as a new antimycobacterial agent.		Antibacterial , DprE1
T25267	Cmpd 339509	Cmpd339509,Cmpd-339509
	Cmpd 339509 is a DprE1 inhibitor. DprE1 is an epimerase required for cell wall biosynthesis.
T79281	Antimycobacterial agent-6
	Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting the Mtb DprE1-C387S mutant. It displays minimal inhibitory ...
T63414	Antitubercular agent-31
	Antitubercular agent-31 is an antitubercular agent that inhibits M. tuberculosisH37Rv (MIC: 0.03 μM) and also inhibits DprE1 (IC50: 1.1 μM).
T63319	Antitubercular agent-32
	Antitubercular agent-32 is a Benzothiazinone derivative that inhibits Mycobacterium tuberculosis and exhibits good metabolic stability and water solubility. Antitubercular agent-32 can act on decaprenylphosphoryl-β-D-rib...
T37880	OPC-167832
	OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-16...