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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11249 | Exatecan | DX-8951,DX-8951f | Topoisomerase |
Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in cancer research. | |||
T78630 | Exatecan mesylate dihydrate | DX-8951 mesylate dihydrate | Topoisomerase |
Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3]. | |||
T16024 | MC-GGFG-DX8951 | Others | |
MC-GGFG-DX8951 is a drug-linker conjugate designed for antibody-drug conjugation (ADC) that demonstrates antitumor activity through the deployment of DX8951, a DNA topoisomerase I inhibitor, connected using the protease-... | |||
T77847 | MC-Val-Cit-PAB-Exatecan | MC-Val-Cit-PAB-DX8951 | |
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a conjugate of the DNA topoisomerase I inhibitor DX-8951 and a cathepsin-cleavable antibody-drug conjugate (ADC) linker, designed for targeted cancer therapy application... | |||
T15098 | Deruxtecan | Others | |
Deruxtecan is an ADC drug-linker conjugate consisting of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker for the synthesis of DS-8201 and U3-1402. | |||
T77901 | Ac-Exatecan | Topoisomerase | |
Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug conjugate (ADC) formulations (ADC Cytotoxin) and acts as an inhibitor of DNA topoisomerase I with an IC50 val... |