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Search Results for " dna-crosslinking "

12

Compounds

Cat No. Product Name Synonyms Targets
T7545 6-Aminonicotinamide Others
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme.
T4047 Bisantrene CL216942 Topoisomerase
Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and ...
T39757 EC2629 EC2629
EC2629 is a highly potent folate- receptor-targeted DNA crosslinking agent.
T29964 Ametantrone Acetate CI-881
Ametantrone Acetate is a topoisomerase II inhibitor of anthrapyrazole family, which can lead to DNA covalent crosslinking.
T24453 Metamelfalan NSC-67781,Metamelfalanum,NSC67781,NSC 67781,m-L-Sarcolysin
Metamelfalan is an alkylating nitrogen mustard with potential antineoplastic activity. It causes crosslinking of DNA, thereby preventing DNA replication and eventually cellular proliferation.
T19193 Amotosalen hydrochloride S-59 Others
Amotosalen hydrochloride (S-59) is a light-activated, RNA-, DNA-crosslinking psoralen compound and is used to neutralize pathogens.
T19560 SGD-1882 PBD dimer Others
SGD-1882 is a agent of cytotoxic, DNA minor-groove crosslinking pyrrolobenzodiazepine (PBD) dimer, and acting as the payload for ADCs.
T61870 (rel)-Oxaliplatin
(rel)-Oxaliplatin is a DNA synthesis inhibitor that induces DNA crosslinking damage, inhibits DNA replication and transcription, and stimulates apoptosis. This compound has applications in cancer research [1] [2] [3].
T16025 SGD-1910 MC-Val-Ala-PBD Others
MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].
T70229 Laromustine
Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanin...
T36745 CDPCP
cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting pr...
T71401 Oxaliplatin-d10
Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and i...
TargetMol