dna topoisomerase ii inhibitor 1 — TargetMol Chemicals

Cat No.	Product Name	Targets
T63360	DNA topoisomerase II inhibitor 1
	DNA topoisomerase II inhibitor 1 is a potent inhibitor of DNA topoisomerase II that arrests the cell cycle in sub-G1 phase and induces apoptosis with anti-value-added effects.
T36968	ARN-21934	Topoisomerase
	ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...	Topoisomerase
T18317	MCC-Modified Daunorubicinol	Others
	Daunorubicinol, a potent antitumor drug-linker conjugate for antibody-drug conjugate (ADC) applications, utilizes Aur0101 (DNA Topoisomerase II inhibitor) connected through the ADC linker[1].	Others
T61054	Type II topoisomerase inhibitor 1
	Type II topoisomerase inhibitor 1 is able to be used in the antibacterial area. Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with a IC50 value of 1.7 nM as well as forms hyd...
T61351	Pixantrone hydrochloride
	Pixantrone (BBR 2778 (free base)) hydrochloride is a mitoxantrone analog compound that acts as a topoisomerase II inhibitor and DNA intercalator. It displays anti-tumor activity [1] [2].
T61045	Topoisomerase I/II inhibitor 2
	Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i...
T61283	Topoisomerase II inhibitor 3
	Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo...
T61017	Topoisomerase II inhibitor 6
	Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in th...
T79539	Topoisomerase II inhibitor 16	Topoisomerase
	Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D...	Topoisomerase
T61431	Topoisomerase IIα-IN-4
	Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demon...
T61481	TP0480066
	TP0480066, a selective topoisomerase II inhibitor, demonstrates excellent inhibitory activity against DNA gyrase (IC50 = 1.10 nM) and topo IV (IC50 = 62.89 nM). This compound exhibits potent efficacy against multiple bac...
T81745	MSN8C
	MSN8C, a mansonone E analog, acts as a novel catalytic inhibitor of human DNA topoisomerase II, inducing apoptosis in cancer cells and exhibiting considerable anti-tumor cell proliferation activity in vitro [1].
T36695	TAS-103
	TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103...
T73700	Daunorubicin citrate
	Daunorubicin (Daunomycin) citrate, a potent anti-tumor anthracycline antibiotic, acts as a topoisomerase II inhibitor. It effectively inhibits DNA and RNA synthesis, diminishes cancer cell viability, and promotes apoptos...
T75303	Suramin
	Suramin is a reversible, competitive inhibitor of protein-tyrosine phosphatases (PTPases) [1], demonstrating potent inhibition against sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) [2]. It a...
T36199	AZD 1152 (hydrochloride)
	AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spi...