5
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1795 | Carfilzomib | PR-171 | Apoptosis , Proteasome , Autophagy |
Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma. | |||
T18320 | MC-Val-Cit-PAB-carfilzomib iodide | MC-Val-Cit-PAB-carfilzomib | Others |
MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADC linker MC-Val-Cit-PAB. | |||
T30806 | CFLZ-567 | ||
CFLZ-567 is a key intermediate for making carfilzomib. | |||
T21342 | CFLZ-171 TFA salt | ||
CFLZ-171 is a key intermediate for the synthesis of carfilzomib. | |||
T80771 | WRR139 | ||
WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1. Moreover, WRR139 amplifies the cytotoxic ... |