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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11388 | Gemilukast | ONO-6950 | Others |
Gemilukast (ONO-6950) is an orally active and potent dual inhibitor of cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2), inhibits LTC 4-induced bronchoconstriction, and is inhibitory to human CysLT1 and CysLT2... | |||
T7841 | MK 571 | L660711,L-660711,MK-571 | LTR |
MK 571 (L660711) is an orally active antagonist of CysLT1 receptor. | |||
T3148 | MK-571 sodium | L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid | Leukotriene Receptor , LTR |
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... | |||
T22668 | Cinalukast | Others | |
CysLT1 leukotriene receptor antagonist | |||
T71273 | CAY10788 | ||
CAY10788 is an antagonist of CysLT1 receptor. | |||
T69278 | FPL-55712 | ||
FPL-55712 is a CysLT1 leukotriene receptor antagonist. | |||
T11860 | LM-1484 | Others | |
LM-1484 displays a higher affinity for 3H-LTC4 sites and is an antagonist of CysLT1 receptor. | |||
T70330 | ONO-2050297 | ||
ONO-2050297 is the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively. | |||
T68392 | ONO-4310321 | ||
ONO-4310321 is a potent, orally available dual CysLT1 and CysLT2 receptor antagonist. | |||
T37016 | Iralukast (CGP 45715A) | ||
Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1. | |||
T31043 | CP-199330 | UNII-V4WYK6T8QA,CP 199330,UNII-74573Q728X,CP-199330 sodium | |
CP-199330 is a cysteyl LT1 receptor antagonist with no hepatotoxicity and is equivalent to the commercially available CYSLT1 receptor antagonists Zafirlukast and Pranlukas. | |||
T37386 | Dihydro Montelukast | ||
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing ... | |||
T72145 | Montelukast dicyclohexylamine | MK0476 dicyclohexylamine | |
Montelukast dicyclohexylamine (MK0476), a potent, selective, and orally active antagonist of the cysteinyl leukotriene receptor 1 (CysLT1), is utilized in the research of asthma, liver injury, and COVID-19. It exhibits a... | |||
T83926 | S-Geranylgeranyl-L-glutathione | GGG | |
S-Geranylgeranyl-L-glutathione acts as a ligand for the orphan G protein-coupled receptor (GPCR) P2RY8, displaying selective affinity by inducing internalization of P2RY8 in preference to the sphingosine-1-phosphate rece... | |||
T37980 | N-methyl Leukotriene C4 | N-methyl Leukotriene C4 | |
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione t... | |||
T21864 | BAY-u 9773 | ||
BAY-u 9773 is a non-selective antagonist of the CysLT receptors (cysteinyl leukotrienes receptors) with about the same IC 50 for CysLT 1 and CysLT 2. BAY-u9773 is used to the inhibit LT responses [1]. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03749 | CYSLTR1 Protein, Human, Recombinant (His) | Human | E. coli |
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and... |