btk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9706	BTK inhibitor 17		BTK
	BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.		BTK
T10629	Btk inhibitor 2	BGB-3111 analog	BTK
	Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.		BTK
T35330	BTK inhibitor 1		BTK
	BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.		BTK
TQ0230	BTK IN-1	SNS062 analog	BTK
	BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).		BTK
T60542	BTK-IN-16		BTK
	BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.		BTK
T40185	BTK inhibitor 19
	BTK inhibitor 19 is a highly selective, covalent BTK inhibitor ( IC 50 = 2.7 nM).
T39612	BTK-IN-5
	BTK-IN-5 is a covalent inhibitor of Bruton's tyrosine kinase (BTK) designed for the treatment of medical conditions including cardiovascular diseases, respiratory diseases, inflammation, and diabetes.
T9813	JAK3/BTK-IN-2		JAK , BTK
	JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor. JAK3/ BTk-in-2 inhibits both BTK and JAK3, which are two important targets IN autoimmune diseases. JAK3/ BTk-in-2 simultaneously inhibits the BTK/JAK3 signaling pathway, sho...		JAK , BTK
T9814	JAK3/BTK-IN-1		JAK , BTK
	JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important targets in autoimmune diseases. JAK3/ BTk-in-1 simultaneously inh...		JAK , BTK
T10628	BTK inhibitor 13		Others
	BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).		Others
T36297	Btk inhibitor 1 hydrochloride
	Btk inhibitor 1 Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.IC50 value:Target: BtkFrom PCT Int. Appl. (2012), WO 2012158843 A2 20121122. [1]. PCT Int. Appl. (2012), WO 2012158843 A2 20121122.
T14956	CHMFL-BTK-01		BTK
	CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.		BTK
T10627	BTK inhibitor 10		Others
	BTK inhibitor 10 is a potent and orally active BTK inhibitor. It has the potential for rheumatoid arthritis treatment.		Others
T62716	BTK-IN-10
	BTK-IN-10 is a potent inhibitor of BTK, acting on wild-type BTK (IC50<5 nM) or mutant BTK (C481S) (IC50<5 nM).
T75124	BTK-IN-24
	BTK-IN-24 (compound 195) is a potent BTK inhibitor via a ubiquitin proteolytic pathway [1] .
T63810	BTK-IN-7
	BTK-IN-7 is a selective and potent BTK inhibitor with an IC50 value of 4.0 nM. BTK-IN-7 exhibits high selectivity at both the enzymatic (ITK>250-fold, EGFR>2500-fold) and cellular levels (ITK>227-fold, EGFR27-fold). BTK-...
T63173	BTK-IN-8
	BTK-IN-8 is a potent, selective, peripheral covalent BTK inhibitor with an IC50 value of 0.22 nM and a Kd value of 0.91 nM. BTK-IN-8 exhibits good potency in whole blood CD69 cells with an IC50 value of 0.029 μM.
T73276	BTK-IN-23
	BTK-IN-23 is a BTK inhibitor with an IC50 value of 12.8 nM, demonstrating kinase selectivity superior to Ibrutinib [1]. It also effectively inhibits BLX and BMX, with IC50 values of 35.6 nM and 5.7 nM, respectively.
T72664	BTK inhibitor 20
	BTK inhibitor 20 is a potent BTK inhibitor with an IC 50 of 8 nM .
T73275	BTK-IN-22
	BTK-IN-22, a BTK inhibitor (IC 50: 0.9 nM), also exhibits inhibition against BLX and BMX with IC 50 values of 1.4 and 1.2 nM, respectively. Demonstrating enhanced kinase selectivity, BTK-IN-22 outperforms Ibrutinib in th...