bcr-abl1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13832	PROTAC BCR-ABL1 ligand 1		Others
	PROTAC BCR-ABL1 ligand 1 is the ligand of PROTAC .		Others
T8882	Vodobatinib	K-0706	Bcr-Abl
	Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.		Bcr-Abl
T61324	BCR-ABL1-IN-1
	BCR-ABL1-IN-1 is a highly potent and orally bioavailable inhibitor, displaying remarkable specificity towards ABL kinase. Notably, this compound holds significant promise for delineating the precise involvement of ABL ki...
T73941	PROTAC BCR-ABL1 ligand 1
	GMB-475, also known as PROTAC BCR-ABL1 ligand 1, allosterically targets and binds to the BCR-ABL1 protein. It effectively recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation...
T8488	GMB-475		Bcr-Abl
	GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati...		Bcr-Abl
T17927	(S,R,S)-AHPC TFA	VH032-NH2 TFA,VHL ligand 1 TFA	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea...		Others , Ligand for E3 Ligase
T2640	Rebastinib	DCC2036,DCC 2036,DCC-2036	Apoptosis , FLT , Bcr-Abl , Src
	DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re...		Apoptosis , FLT , Bcr-Abl , Src
T5177	Asciminib	ABL001	Bcr-Abl
	Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).		Bcr-Abl
T2328	Radotinib	IY-5511,Supect	Bcr-Abl
	Radotinib (IY-5511), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) w...		Bcr-Abl
T10489	BCR-ABL-IN-2		Others
	BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).		Others
T70167	BP-5-087
	BP-5-087 is a STAT3 inhibitor, combining with BCR-ABL1 inhibition to overcome kinase-independent resistance in chronic myeloid leukemia.
T63226	Asciminib hydrochloride
	Asciminib (ABL001) hydrochloride is a selective and potent mutant BCR-ABL1 inhibitor that inhibits Ba/F3 cell growth (IC50: 0.25 nM).
T22067	CHMFL-ABL-053
	CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC 50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively. CHMFL-ABL-053 is a potentiall...