8
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12575 | Unesbulin | PTC596 | Apoptosis , BMI-1 |
Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1). | |||
T16680 | PTC-028 | Apoptosis , BMI-1 | |
PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspas... | |||
T2345 | PTC-209 | PTC209,PTC 209 | BMI-1 , Autophagy |
PTC-209 is a potent and selective BMI-1 inhibitor. | |||
TN2507 | 1,6,7-Trihydroxyxanthone | DNA/RNA Synthesis | |
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells. | |||
T62617 | QW24 | ||
QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer. | |||
T82852 | BMI-Glu | ||
BMI-Glu, a selective γ-glutamyl transpeptidase (GGT) fluorescent probe, exhibits a Michaelis constant (Km) of 69.63 µM and is characterized by its high sensitivity, good water solubility, and biocompatibility [1]. | |||
T63374 | SH498 | ||
SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects. | |||
T6178 | PTC-209 hydrobromide | PTC-209 HBr | BMI-1 , Autophagy |
PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs). |